Graduate Faculty Directory
Bin Chen
Department of Pharmaceutical Sciences
Education
- BS, MS (Nanjing)
- PhD (Catholic University Leuven, Belgium)
Faculty Appointments
Assistant Professor of Phamaceutical Sciences
Research Interest
Photo-activated tumor vascular targeting and imaging
Pharmacological evaluation of natural products with anti-tumor activities
Synopsis
My research focus on targeting tumor blood vessels for cancer therapy. We are particularly interested in using photo-active drugs(photosensitizers) to modify tumor vascular function. Current research projects include characterizing blood vessel structural and functional changes induced by vascular targeting therapy, studying the interaction between vascular targeting therapy and conventional tumor cellular targeting therapy, and elucidating the molecular mechanism of vascular-targeting therapy. Fluorescence imaging is an important component of our research. We have developed an integrated fluorescence-based imaging system that allows continuous non-invasive imaging in real time at different anatomic levels from the whole body level down to the subcellular level. We are also interested in studying natural products with anti-tumor activities. An ongoing project is to determine the anti-tumor mechanisms of tanshinone.Publications & Presentations
- Chen B, Pogue BW, Hoopes PJ, Hasan T. Vascular and cellular targeting for photodynamic therapy (review). Crit Rev Eukaryot Gene Expr. 2006, 16: 279-306.
- Chen B, Pogue BW, Luna J, Hardman R, Hoopes PJ, Hasan T. Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism and therapeutic implications. Clin Cancer Res. 2006, 10: 917-23.
- Chen B, Pogue BW, Hoopes PJ, Hasan T. Combining vascular and cellular targeting regimens enhances the therapeutic effect of photodynamic therapy. Int J Radiat Oncol Biol Phys. 2005, 61: 1216-26.
- Chen B, Pogue BW, Zhou X, O’Hara JA, Solban N, Demidenko E, Hoopes PJ, Hasan T. Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model. Clin Cancer Res. 2005, 11: 720-7.
- Pogue BW, Gibbs SL, Chen B, Savellano M. Fluorescence imaging in vivo: raster scanned point-source imaging provides more accurate quantification than broad beam geometries. Tech Cancer Res Treat. 2004, 3: 15-21.
- Chen B, Pogue BW, Goodwin IA, O’Hara JA, Wilmot CM, Hutchins JE, Hoopes PJ, Hasan T. Blood flow dynamics following photodynamic therapy with verteporfin in the RIF-1 tumor. Radiat Res. 2003, 160: 452-459.
- Chen B, Busan A, Landuyt W, Ni Y, Gaspar R, Roskams T, De Witte P. Potentiation of photodynamic therapy with hypericin by mitomycin C in the RIF-1 mouse tumor model. Photochem Photobiol. 2003, 78: 278-282.
- Pogue BW, O'Hara JA, Demidenko E, Wilmot CM, Goodwin IA, Chen B, Swartz HM, Hasan T. Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity. Cancer Res. 2003, 63: 1025-33.
- Chen B, Roskams T, Xu Y, Agostinis P, De Witte P. Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model. Int J Cancer. 2002, 98: 284-90.
- Chen B, Xu Y, Roskams T, Delaey E, Agostinis P, Vandenheede JR, De Witte P. Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model. Int J Cancer. 2001, 93: 275-82.
Contact Information
Office:
Pharmacology/Toxicology Center
Room # 244
Box # 80
Phone: 215.596.7481
Email: b.chen@usp.edu
