Graduate Faculty Directory
John A. Beutler
Education
- PhD (PCP&S)
- MSc (Philadelphia College of Pharmacy and Science)
- BA (Vassar College)
Faculty Appointments
Adjunct Associate Professor of Cell Biology
Professional Information
Staff Scientist
Molecular Targets Development Program
Center for Cancer Research
National Cancer Institute
Publications & Presentations
- "Synthesis and structure activity studies of chweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity." JD Neighbors, MS Salnikova, JA Beutler and DF Wiemer. Bioorg. Med. Chem. 14: 1771-1784, 2006.
- "Inhibition of transcription factor NF-kB signaling proteins IKKB and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity." MC Liang, S Bardhan, EA Pace, D Rosman, JA Beutler, JA Porco Jr, and TD Gilmore. Biochem. Pharmacol. 71:634-645, 2006.
- "Selective inhibition of HIV-1 reverse transciptase-associated ribonuclease H activity by hydroxylated tropolones." SR Budihas, II Gorshkova, SA Gaidamakov, A Wamiru, MK Bona, MA Parniak, RC Crouch, JB McMahon, JA Beutler and SFJ LeGrice. Nucl. Acids Res. 33:1249-1256, 2005.
- "Secondary metabolites of Phlomis viscosa and their biological activities." I Calis, H Kirmizibekmez, D Tasdemir, P Ruedi, AA Donmez, FN Yalcin, E Kilic, M Ozalp, and JA Beutler. Turkish J. Chem. 29: 71-81, 2005.
- "Synthesis of nonracemic 3-deoxyschweinfurthin B." JD Neighbors, JA Beutler, and DF Wiemer. J. Org. Chem. 70: 925-931, 2005.
- "Synthesis of Vedelianin Analogues." American Chemical Society Great Lakes Regional Meeting, June 2006. Nolan R. Mente, Jeffrey D. Neighbors, John A. Beutler, David F. Wiemer.
- "Exploring the Mechanism of Specific Inhibition of the HIV-1 RNase H Domain by beta-Thujaplicinol" Cold Spring Harbor Meeting on Retroviruses, May, 2006. G. Beilhartz, D. Eggink, S.F.J. Le Grice, J.A. Beutler, M. Gotte.
- "Identifying Small-Molecule Antagonists of HIV-1 and Human Ribonuclease H Activity via High-Throughput Screening." 7th International Meeting on Ribonucleaes, Stara Lesna, Slovak Republic, June 2005. RJ Crouch, J Beutler, S Budihas, M Parniak, A Wamiru, R Gardella, J Wilson, S Gaidamakov, N Shulley, K Chan, S Le Grice, J McMahon.
- "The Schweinfurthins: Issues in Development of a Plant-Derived Anticancer Lead." Frontis Workshop, Medicinal and Aromatic Plants, Wageningen, Netherlands, April, 2005. JA Beutler.
- "3-Deoxyschweinfurthin B: A Synthetic Schweinfurthin with Anticancer Activity" Am. Chem. Soc. Midwest Regional Mtg., October, 2004. JD Neighbors, M. Salnikova, DF Wiemer, JA Beulter.
Contact Information
Office:
Molecular Targets Development Program
Bldg. 560-15, NCI at Frederick
Frederick, MD, 21702-1201,
Phone: 301.846.1942
Email: jb123w@nih.gov
